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In lyophilized (freeze-dried) form, it is stable at room temperature for short periods but should be stored at -20C for long-term preservation
PARPs, involved in DNA repair, consume NAD+ during frequent repair events in older cells
Important Notes Practical points that keep administration safe and consistent
Gastrointestinal symptoms (more common with oral preparations): Mild nausea or upset stomach Diarrhoea (typically with very high doses) Other effects: Headache, particularly when treatment is first initiated Dizziness or light-headedness Skin reactions such as mild rash or itching Temporary reddish discolouration of urine (chromaturia) after hydroxocobalamin injections, which is harmless It is important to note that many symptoms attributed to B12 supplementation may actually represent the body's response to correcting a deficiency
Researchers appreciate the easier handling of capsules over powder form, reducing measurement errors and contamination risks in the lab
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